Coenzyme Q10 deficiency is a factor in numerous diseases including heart
failure. Folkers K: Heart failure is a dominant deficiency of coenzyme Q10 and
challenges for future clinical research on CoQ10. Clin Investig
71:S51-4, 1993.
Heart failure patients with abnormally low levels of coenzyme Q10 and
vitamin E have a reduced survival rate. Jameson S: Statistical data support
prediction of death within six months on low levels of coenzyme Q10 and other
entities. Clin Investig 71:S137-9, 1993.
Patients with congestive heart failure felt less tired, their general
activity tolerance increased and breathing difficulties at rest disappeared when
they were given 100 mg per day of coenzyme Q10 supplements. Mortensen SA et al: Long-term coenzyme Q10 therapy: a major advance in the
management of resistant myocardial failure. Drugs Exp Clin Res
11(8):581-93, 1985.
Positive results of congestive heart failure treatment with coenzyme Q10 have
been above and beyond the clinical status obtained from treatment with
traditional principles, and reduces hospitalization and the incidence of serious
complications.
Mortensen SA: Perspectives on therapy of cardiovascular diseases with CoQ10. Clin
Investig 71:S116-23, 1993.
Similar results reported in: Lampertico M et al: Italian multicenter study on
the efficacy and safety of CoQ10 as adjuvant therapy in heart failure. Clin
Investig 72:S129-33, 1993.
And in: Morisco C et al: Effect of coenzyme Q10 therapy in patients with
congestive heart failure: a long-term multicentre randomized study. Clin
Investig 71:S134-6, 1993.
2664 patients from 173 Italian centres given 50-150 mg CoQ10 daily
experienced more than 70% improvement in cyanosis, oedema, palpitations and
other symptoms
Baggio E et al: Italian multicenter study on the safety and efficacy of coenzyme
Q10 as adjunctive therapy in heart failure. Mol Aspects Med
15s:2287-s294, 1994.
