A patient with severe sleep disturbance and treated with vitamin B12
experienced progressive improvement in his sleep disturbance. He was able to
advance the timing of his sleep period for the first time in nearly 10 years
and to follow a normal 24 hour sleep-wake regimen. Kamgar-Parsi B et al:
Successful treatment of human non-24-hour sleep-wake syndrome. Sleep
6(3):257-64, 1983.
2 adolescent patients with persistent sleep-wake disorders experienced an
immediate improvement after the administration of high doses of vitamin B12.
Neither had shown any other laboratory or clinical evidence of B12 deficiency.
Ohta T et al: Treatment of persistent sleep-wake schedule disorders in
adolescents with methylcobalamin (vitamin B12). Sleep 14(5):414-8, 1991.
